Organization and function of the cell surface – University of Copenhagen

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Organization and function of the cell surface

The shape of the cell has a great impact on how proteins and lipids organize to form the cellular surface.

In both cancer metastasis and during viral infection, the cell surface changes shape with consequent important implications for the distribution of membrane proteins and for the physical state of the cell membrane. Membrane proteins are active in shaping membranes into highly curved buds and tubes, a process which can be amplified by curvature induced sorting of proteins.

This project deals with how curvature acts to recruit membrane associated proteins and how membrane proteins affect the physical properties of the cell surface like stiffness, curvature and phase behavior.

Supported by a Sapere Aude Grant from the Danish Research Councils.