Force mapping during cancer cell division and invasion – University of Copenhagen

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Force mapping during cancer cell division and invasion

The cells of living tissues are constantly exposed to forces, they experience tension, compression, pressure and shear stress. Also, cells can themselves grow and divide, change shape and actively move, hence exerting forces on their microenvironment.

In this project, we focus on the mechanics of cancer cell invasion, both in terms of how cancer cells differ from non-cancerous cells, and the mechanical interaction between cancer cells and their microenvironment. Cancer cells are deadly once they cross the endothelial barrier of the blood stream, invade into local and distant tissue, and proliferate in vital organs.

Thus, we will focus on mapping the mechanical forces and dynamics associated with these processes to better understand the mechanisms and uncover potential avenues of inhibition. This project is a collaboration between physicists from NBI and cancer cell biologists from BRIC, KU.

Supported by a Research Project 2 Grant from the Danish Research Councils.